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Black Seed Oil
  Definition of Black Seed Oil.
  Chemical composition and biochemistry of Black Seed.
  The nature of pharmacology and toxicology of Black Seed.
  Prophet hadith and expert statement of Black Seed.
  Benefit and advantage ( More 100 active material in Black Seed).
  Allergy-Research paper.
HEALTHY LIFE
NUTRITIOUS OF BLACK SEED TO HEALTH

 

 Following are nutrition and advantage Black Seed specifically to on type of paint and it was proved scientifically and clinical trial

 

Head

Chest

 Stomach

 Waist-feet

Migraine, earache

Inflammation

 

Coral stone

Gout

Toothache, bloody gum

Jaundice

Bile stone

man hardness

Migraine

Cough

Gastric

Smoothen menstrual recycle

Dandruff

tuberculosis

Ulcer

dynamite sexual

facial palsy

Bronchial asthma

Cardiac asthma

Treat digestion system

 

Mistress, ophoritis, indomeferitis

Amnesia

watery lung

 

Dysmenorrheal

 

 

 Expectorant

 Palpitation

Destruct organism in heart, liver and kidney

Premature ejaculation

Make intelligent mind

Increase mother-milk

Murder parasite

Hemorrhoids

Influenza

Treat respiratory system

Chronic dysentery

paralyses

Cataract

Cirrhosis of liver

Diarrhea

Anti-fungus

Gum inflammation

Improve breast contour

Colic

Anti bacteria, Anti oxide

 

Following are nutrition and advantage Black Seed and their function generally to the human body and it was proved scientifically and clinical trial:

 Wound

Cold

Infection

Dry skin

Psoriasis

Eczema

Allergies

Bee venom and hornet

The mad dog bite

Itchy skin

Strengthened the gland

Prevent cancer

Overcome skin disablement

Diabetes mellitus

Anti-fungus

Anti-bacteria

Anti-oxidant

Anti-inflammation

Snake bite

Myrmecia

Eruptions

Puerperal fever

Sclerosis

Orchitis

corns

warts

calluses

swelling

Bilious ailments

Anti-pyretic

Rheumatism

Analgesic

Reduced the rate content of blood

Antihistamine activity-suitable to treat allergic

Black Seed' rich with fatty acid poly unsaturated who help to issue prostaglandin E1 his function closely related with following matters :-

Strengthen immunes system

 Improve sugar metabolic

Protect gut wall

Blood clots

skin infection

 

 

If composed with antibiotic as streptomycin and  Black Seed' gentamycin can stimulate all antibacterial activity.
 

 

If composed with erythromycin, tobramycin, doxycydine and  Black Seed' ampicillin show antibacterial function a more powerful until capable murder E-Coli, pathogen organism as Candida alb cans, staphylococcus and yeast.
 

  

If composed with Black Seed' garlic function harmonize back autoimmune disorder, and prevent immune cells from destroy active cell . (Mean Autoimmune disorder state where patient suffer cause his body system attack his body physical.

 

Black Seed's content' especially fatty acid poly unsaturated also stimulate productivity growth prostaglandin E1, one element as if hormone that functions as stabilizer to some function to person body as :-

i. Brain function

ii. Nerve function

iii. Heart function

 

 

ALLERGY – (Example Sinus and Asthma)-Testimony

Allergy is word whose used to describe any situation, sneeze attacks from and watery eyes on a hot day, until to red rash itchy and breathing wheezing after rub pet animal or lip and tongue swelling and sickness after eating peanut. Briefly, allergy mean “reaction turning” , namely reaction mechanism body's defense for materials normally harmless. Most allergy always happens is :

     i.                    Allergy rhinitis and allergy conjunctivitis

ii.                   Asthma

iii.                 Rash on skin that itchy

iv.                Food Allergy

v.                  Allergy to bee' sting and  hornet's sting

vi.                Sinus

 

  HOW ALLERGY HAPPENED.

Allergy incident beginning  when a person exposed to any allergen as microbes house, pet animal, pollen and fungus that cause allergy production of antibodies called imunoglobin E (IgE). Allergy antibody imunoglobin (IgE) stick herself to lymphocytes or antigen that called mast cell. Mast cell containing histamine (a kind of protein), chemoatractants and other chemicals call leukotrin afford expand blood vessel and constrict smooth muscle (smooth muscle) that surround lung airway. Mast cell stick by allergy antibody imunoglobin (IgE) in fact can be found on the whole skin and layer nose, mouth, tongue, lung route and small intestine. It (mast cell) stick by allergy  antibody imunoglobin (IgE) just now will break and release histamine, leukotrin and chemoatractants that would eventually produce reaction allergy. Mast cell will also attract other cell, especially white blood cell called eosinphil, irritate and damage cell. Histamine and leukotrin will cause sneeze and itchiness and swelling on the skin, in cavity lung (airway), and in strata nose. This resulted itchy bulge red colour on the skin, asthma and nose stopped up. Inflammation situation that encourage by the presence eosinphil enhance layer nose sensitivity and lung and produce chronic symptom.

ANTI HISTAMINE ACTIVITIES-IMPACTS TO ALLERGY (ALLERGY/SINUS)-Testimony 

 

Histamine (hist = mean it comprise from dregs waste (residue) histidine, while amine = because it is vasoactive amine that causes several indications allergic (allergic symptoms) as inflammation and constriction for smooth muscle.

Histamine is a important proteins that cause allergic effects. While allergic is because by immune reaction for materials customary harmless as pollen and dust (normally known  as allergen) shall be affixed to lymphocytes those mentioned as antigen. Antigen react that were mast cell (mast cell). In fact to happen this interaction antibody allergy molecule immunoglobulin (IgE) who are free afloat, shall be affixed to mast cell surface receptor. Mast cell with their own react with dismiss histamine, leukotrin and chemoatractants that finally produce allergy reaction.

Because of the reaction just because by material which actually harmless in the body, then to let immunes system works and to react for elements cause of allergic is mean a interference in the body. Therefore use anti histamine can help body so that can live with safer and comfortable with the immune system no need to act by mistake.

Medical experts outcome of the study since a long time find that nigellone is major active ingredient that successfully dissociated from grain nigella sativa. Dr. Mahouz and Dr. El-Dakhakny find that chemical properties and pharmacology very suitable to protect their experimental animal (guinea pigs) from histamine bronchopasm that induce.

In the year 1960, was reported that crystalline nigellon has use as substance to treats children and also adult who already have bronchial asthma, and find that it own value therapeutic beside no containing toxic substance. However even his reaction's impact just discernible after a few days.


In the year 1993, Dr Nirmal Chakravarty had committed single study to confirm that crystalline nigellon maybe contribute as deterrent agent release histamine.

Inhibition for release antigen-induced histamine in picture 1. White egg were used as antigen. Concentration nigellon at the rate 11ug / ml gives 50 % retarding potential for release histamine



 

                  Picture : 1            

For compound 48/80 those included (induced), histamine discharged at the rate an almost identical as in the case nigellone (picture 3). 50% inhibition release histamine had happened at the rate 15ug / ml

 

  

  Picture : 2

Bend line is inhibition trace of action nigellon over release histamine supported by calcium ionophore A23187 obtain is the same with release before it, but his release obtain little less sensitive for nigellon. Like picture 3, 26ug / ml nigellon cause of inhibition 50 % release histamine.
 

  

  Picture : 3

Capacity nigellon as deterrent agent and inhibitor to release histamine likely originate from restriction kinase C protein and reduce thickness  intracellular calcium. Metabolic inhibition energy oxidative (oxidative energy metabolism) may also played a role.

The impact nigellon to on release histamine supported by stimulation kinase C protein also result in shut it production kinase C protein to  other cell. Because of kinase C protein very significant in reaction by biology include encouraging formation cancer then get conclusion that it is seen so potential if used as a principal ingredient anti cancer.
 

 ABILITY AS ANTI TUMOUR

In the year 1998 scientist from The college of pharmacy, university of Kentucky, USA, study by activity in vitro anti tumour to black seed raw (crude) and also component black seed was filtered. Two important component filtered is thymoquinone (TQ) and dithymoquinone (DIM). 

Picture 4. Thymoquinone dan Dithymoquinone

  

Picture 4. formulation structure thymoquinone ( TQ) and dithymoquinone (DIM )

In this study, raw component and extract black seed oil and also quinines TQ and DIM filter assess in vitro to determine the level toxic for pancreatic Aden carcinoma cell line CFPAC-1 human, uterine sarcoma cell line MES-SA and Varian MDR, Dx5 , leukekik cell line K562 human and MDR Varian R7.

TQ Toxic rate and DIM compared with standard cancer treatment, doxorubicin DOX and topside, ETP. Both drug stated have been proven effective reduce in vitro cytoxicity for cell that produce radical material.

This study expose quinines TQ and DIM, two important content Nigella sativa, so destructive (cytotoxic) for some type of cell in human vitro. Similarly both TQ and DIM equivalent his destroyer's impact to MDR tumour cell. This give dependence that it maybe useful as drug anti cancer beside useful to treat MDR tumour resistant. 

The content of Grain active Nigella sativa containing the part of fatty acid study of anti tumour activity over Ehrlich ascites carcinoma (EAC), Dalton's cell lymphoma ascites (DLA) And Sarcoma-180 (S-180). Those animal accept EAC cell and black seed obtain fixed normal without signs tumor formation impact. This situation explained that active ingredient have the effect capacity as anti tumour over EAC. Results of studies also found that animals accept DLA cell and black seed show that his active ingredient can inhibit development and under environment tumor formation from 50% over with the animal who do not accept that active ingredient.

  

 
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