Histamine (hist = mean it
comprise from dregs waste
(residue) histidine, while
amine = because it is
vasoactive amine that causes
several indications allergic
(allergic symptoms) as
inflammation and
constriction for smooth
muscle.
Histamine is a important
proteins that cause allergic
effects. While allergic is
because by immune reaction
for materials customary
harmless as pollen and dust
(normally known as
allergen) shall be affixed
to lymphocytes those
mentioned as antigen.
Antigen react that were mast
cell (mast cell). In fact to
happen this interaction
antibody allergy molecule
immunoglobulin (IgE) who are
free afloat, shall be
affixed to mast cell surface
receptor. Mast cell with
their own react with dismiss
histamine, leukotrin and
chemoatractants that finally
produce allergy reaction.
Because of the reaction just
because by material which
actually harmless in the
body, then to let immunes
system works and to react
for elements cause of
allergic is mean a
interference in the body.
Therefore use anti histamine
can help body so that can
live with safer and
comfortable with the immune
system no need to act by
mistake.
Medical experts outcome of
the study since a long time
find that nigellone is major
active ingredient that
successfully dissociated
from grain nigella sativa.
Dr. Mahouz and Dr.
El-Dakhakny find that
chemical properties and
pharmacology very suitable
to protect their
experimental animal (guinea
pigs) from histamine
bronchopasm that induce.
In the year 1960, was
reported that crystalline
nigellon has use as
substance to treats children
and also adult who already
have bronchial asthma, and
find that it own value
therapeutic beside no
containing toxic substance.
However even his reaction's
impact just discernible
after a few days.
In the year 1993, Dr Nirmal
Chakravarty had committed
single study to confirm that
crystalline nigellon maybe
contribute as deterrent
agent release histamine.
Inhibition for release
antigen-induced histamine in
picture 1. White egg were
used as antigen.
Concentration nigellon at
the rate 11ug / ml gives 50
% retarding potential for
release histamine
Picture
: 1
For compound 48/80 those
included (induced),
histamine discharged at the
rate an almost identical as
in the case nigellone
(picture 3). 50% inhibition
release histamine had
happened at the rate 15ug /
ml
Picture : 2
Bend line is
inhibition trace of action
nigellon over release
histamine supported by
calcium ionophore A23187
obtain is the same with
release before it, but his
release obtain little less
sensitive for nigellon. Like
picture 3, 26ug / ml
nigellon cause of inhibition
50 % release histamine.
Picture : 3
Capacity nigellon as
deterrent agent and
inhibitor to release
histamine likely originate
from restriction kinase C
protein and reduce thickness
intracellular calcium.
Metabolic inhibition energy
oxidative (oxidative energy
metabolism) may also played
a role.
The impact nigellon to on
release histamine supported
by stimulation kinase C
protein also result in shut
it production kinase C
protein to other cell.
Because of kinase C protein
very significant in reaction
by biology include
encouraging formation cancer
then get conclusion that it
is seen so potential if used
as a principal ingredient
anti cancer.
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